Publications

BMC bioinformatics. 2011-11-09; 12.434.

ProPhylo: partial phylogenetic profiling to guide protein family construction and assignment of biological process

Basu MK, Selengut JD, Haft DH

PMID: 22070167

Abstract

Phylogenetic profiling is a technique of scoring co-occurrence between a protein family and some other trait, usually another protein family, across a set of taxonomic groups. In spite of several refinements in recent years, the technique still invites significant improvement. To be its most effective, a phylogenetic profiling algorithm must be able to examine co-occurrences among protein families whose boundaries are uncertain within large homologous protein superfamilies.

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